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When I lecture the first problem I face is not convincing the audience that I have the right answers but convincing them that they have been asking the wrong questions. The conflict is not primarily about Genesis, nor does it involve a clash between science and religion, or between reason and faith. It would be much more accurate to say that it involves a clash between two religions and two definitions of science. | ||||
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Plants Maximize Pipeline Efficiency 02/28/2003 How did the plant achieve this optimization? Notice the flaky reasoning in the press release (emphasis added): [Co-author John S.] Perry says the plant also wants to minimize the energy and material it puts into building the water conduit system so it can conserve energy for the ultimate goal: reproduction. If you are an engineer building a plumbing system, you want to deliver the most water per unit of energy with the least amount of material the cheapest and most effective conductance system you can design, he says. Let us ask, does a plant want anything? Are plants engineers? The quote only makes sense if an external Engineer made these things. Plants are so good at doing what they do with the dew, because they do what they were designed to do. Please do give due honor to Whom honor is due.Evolution Teaching Deficient 02/27/2003 Brian J. Alters of the Evolution Education Research Centre at Montreals McGill University is alarmed at the ignorance of evolution among college students, reports EurekAlert. The deficiency is seen not only among those who have avoided math and science, but even among those who have had extensive science courses. So he and colleague Craig Nelson of Indiana University have written a paper in the journal Evolution entitled, Perspective: Teaching Evolution in Higher Education, in which they address the problem of students prior conceptions and how to address them: We also attend to concerns about coverage of course content and the influence of religious beliefs, and provide helpful strategies to improve college-level teaching of evolution. The key words listed in the abstract include creationism, evolution, prior conceptions, religious beliefs and student-centered instruction. We have the perfect solution. Turn students on to Creation-Evolution Headlines and assign the Concise Guide to Evolutionary Theory and Baloney Detector as required reading.New Java Man As Controversial As Old Java Man 02/27/2003 National Geographic says that a new Homo erectus skull named Sm4 reported from Java raises questions on the human family tree. Scientists differ where it fits. Tokyo anthropologist Hisao Baba and team, writing in the Feb. 28 issue of Science, are trying to make it a transitional form between African Homo erectus and modern humans, but others think it has nothing to do with the human lineage. Ann Gibbons in her Science News of the Week commentary says, Modern anatomy in the interior of this skull surprised researchers. Furthermore, dating of the geological strata in the area is tricky; Rutgers geochronologist Carl Swisher states, Depending on who you talk to it could be half a million years old or less than 100,000, possibly making it, along with Ngandong, contemporary with Homo sapiens. Kenneth Mowbray of the American Museum of Natural History reminds us that anatomy size cannot be a reliable indicator of differences between species; consider how a tall basketball player and a vertically-challenged person are polar opposites in terms of size, but both fully Homo sapiens. I think theyre grasping at straws to suggest that Sm 4 is an intermediate form, he said. When every new find messes up the theories, its an indication the approach is wrong. Do you notice, also, the ambition to find those illusive transitional forms? The old 1891 Java Man is now just a historical footnote, a misinterpretation by an ambitious enthusiast, as this one appears destined to be.Encyclopedia of Evolution Reviewed by Evolutionist 02/27/2003 In the Feb. 27 issue of Nature, Joel Peck at the UKs Centre for the Study of Evolution gives only subdued praise to Oxfords two-volume, 4-kg Encyclopedia of Evolution (2002). He also has some criticisms and interesting observations (emphasis and bullets added): The encyclopedia contains 365 articles written by 330 different authors. Plagiarized, perhaps, because bored students assigned to write term papers on evolution will probably parrot whatever these 330 soothsayers say, whether on art, warfare, ape culture, globalization, or motherhood, without questioning it. To see how far evolutionary imperialism has invaded other territories, one need look no farther than a few pages down in the same issue of Nature, where two teams of evolutionary sociobiologists debate the evolution of religion and belief in supernatural punishment, based on evolutionary game theory. (See the Sept. 3 2002 headline for a similar example and important commentary.) One piece of Pecks advice should be emphasized: you should read material from other sources (like you are right now) to obtain a balanced view. How about Pascals version of game theory?Stem Cell Update 02/26/2003: Two teams reporting in the Feb. 26 online preprints of the National Academy of Sciences report success using adult stem cells. A University of Chicago team identified pluripotent stem cells from blood monocytes, and a team from University of Oslo and Tulane succeeded in getting stem cells from bone marrow to act like and repair airway epithelial cells. Next headline on: Health. Next headline on: Politics and Ethics.
Sexual Selection: Darwin Was Wrong 02/26/2003 We add a word of caution, that Roughgarden seems a little intent on rationalizing feminism and homosexuality by observing animal behavior, which is also inadequate even as an approach for humans. Formerly Jonathan, transgender homosexual Joan Roughgarden has a lifestyle to whitewash. Paul Vasey, not as revolutionary as Roughgarden, explains: People often look to animals to decide for themselves whats natural and whats not natural. I dont think thats necessarily a good thing to do. I mean, animals engage in cannibalism and infanticide. They also dont take care of elderly individuals. Just because animals do something doesnt make it right or wrong. To that we add that we are men, not beasts; we have a soul, and we have the Manufacturers operating instructions.Your Model Train Set 02/25/2003 Model train enthusiasts never had it so good. Imagine five different models of finely-crafted engines, all in perfect working order, and enough track to cover a city. Thats what each of us has, right now, inside our cells. But dont feel top dog; even lowly bacteria have them, too. To prove were not making this up, read The Molecular Motor Toolbox, a Review article in the current issue of the journal Cell, by Ronald D. Vale of the Howard Hughes Medical Institute. He begins, A cell, like a metropolitan city, must organize its bustling community of macromolecules. Setting meeting points and establishing the timing of transactions are of fundamental importance for cell behavior. The high degree of spatial/temporal organization of molecules and organelles within cells is made possible by protein machines that transport components to various destinations within the cytoplasm.Vale reviews the five major motor engine families that ferry cargo around the cell: actin, dynein, conventional homodimeric kinesin, heterotrimeric kinesin II, and Unc104/KIF1. These engines show remarkable flexibility and diversity in living things, from plants to sea squirts to fungi to worms, and are highly conserved from the smallest organisms to the largest. What about the switching? What keeps the engines from colliding on the tracks? To achieve law and order on the intracellular highways, the multiple cargo-carrying motors in a single cell must be regulated. In the majority of animal cells, individual organelles switch frequently between anterograde (microtubule plus-end-directed) and retrograde (minus-end-directed) movement .... In most cells, relatively little is known about the regulation and coordination of bidirectional motion. ... individual cargoes move primarily unidirectionally in these extended processes, and a switch in direction occurs when cargoes reach the ends of these elongated structures.There is an unknown switching mechanism at so-called turnaround zones on the microtubules that dynein and kinesin engines travel on. The microscopic observations of cargo transport in axons and flagella raise a number of similar questions. How do the opposite polarity motors, kinesin and dynein, coordinate their activities? What kind of machinery processes the incoming cargo and switches motor direction at the turnaround zones? Molecular answers to these questions are beginning to emerge but are far from complete.As a sidelight, another review article in the same issue of Cell by a team from UC San Diego describes how these motors are involved in tugging the chromosomes apart during cell division (mitosis). In fact, the whole Feb. 21 issue is a good source for current knowledge about the cells inner workings: mitochondria, cell division, signalling, transport, etc. But back to our story. Vale points to fascinating indications that the motors signal each other and coordinate their actions. After discussing some of these possibilities, he concludes, Fifteen years ago, only a few molecular motors were known. In contrast, complete inventories of molecular motors are now available in a number of diverse organisms. While these remarkable accomplishments have answered many questions, the genomic inventories also have exposed many areas of ignorance. Well, back to the lab; gotta get to work. Biochemistry can be fun. You get to play with miniature railroads. Nature Science Update reports that NASA engineers are studying the intracellular railroad for spacecraft ideas. UCLA got a $30 million NASA grant to begin the Institute for Cell Mimetic Space Exploration, whose mission is to come up with biology-inspired devices that could facilitate space travel 30 years from now. Some of the plans include imitating actin. Vales article is another of many we have reported that seems schizophrenic. On one side of his brain, he marvels at the engineering and design, and on the other side, attributes it all to chance. Here is Vales storytelling about how this coordinated transportation system arose: The complexity of these Toolbox motors expanded in higher eukaryotes through gene duplication, alternative splicing, and the addition of associated subunits, which enabled new cargoes to be transported. Impressed? Well, for crying out loud, how did the motors get there in the first place? Marvel at this explanation: Recent genomic and functional studies suggest that five cargo-carrying motors emerged in primitive eukaryotes and have been widely used throughout evolution. There you have it, folks. They just emerged. The miracle alarm just went off. Its time to declare an emergency and kick the evolutionary gullibility out of science.Shoot Bullets at Ice and Create Life 02/24/2003 New Scientist reports that NASA researchers shot bullets at ice and saw sparks. They think this is maybe a way the icy moon Europa could have life. Meteorites bombarded the ice, melting methane and ammonia and water. The shock also produced electricity that might help form amino acids, the building blocks of life, like Stanley Miller did with his spark-discharge apparatus. We wont know till we send a spacecraft there, maybe around 2011. This is so lame it hardly deserves a comment. Evolutionists see the forces of destruction as the new creator gods. Lightning, chance and meteor blasts are now the cosmic garden of Eden. Should they teach this nonsense in the schools?Another Rotary Motor Found in Cells 02/24/2003 Another member of the ATPase (ATP synthase) superfamily has been shown to rotate and produce three ATP per cycle. The well-known FoF1-ATP synthase was imaged in rotation about five years ago. Another enzyme, VoV1-ATPase, was known to be structurally similar and has been assumed to rotate also, but experimental evidence was lacking. The Japanese have done it again. They attached a bead to the stalk and imaged the tiny molecular machine rotating counterclockwise at about 144 rpm, which they assume is the natural rotation rate without the bead attached. VoV1-ATPase is responsible for acidification of eukaryotic intracellular compartments and ATP synthesis in Archaea and some eubacteria. FoF1-ATP synthase resides in the mitochondria and chloroplasts; VoV1-ATPase is embedded in various intracellular acidic compartments. This enzymes D subunit acts like a rotor shaft, analogous to the gamma subunit of F1ATPase. The experimental results are written up in the Proceedings of the National Academy of Sciences online preprints for Feb. 21. How they work: The Fo and Vo subunits of the machines are embedded in the membranes and use proton motive force to rotate. The F1 and V1 subunits are where ATP synthesis takes place. They contain six lobes that are acted on by a rotor shaft, or camshaft, attached to the rotating portion. The six lobes come in pairs. As the camshaft turns, it causes each pair to cycle through the manufacturing steps: load the ingredients (ADP and phosphate), squeeze them together into ATP, then eject the ATP into the surrounding medium. Each pair is undergoing one of these stages every 120o turn of the camshaft, so that 3 ATP are produced for every full turn. ATP is the energy currency used by most processes in the cell. On a busy day, your miniature motors can recycle an amount of ATP equal to or exceeding your body weight. The discovery of rotary motors like ATP synthase and the bacterial flagellum in living cells has caused a great deal of excitement and astonishment, not just because they are cute, but they are extremely efficient (nearly 100%, utilizing the Brownian motion of the cell to their advantage), and absolutely essential to life. Add this one to the growing list of molecular machines. Did you notice it exists in Archaea and eubacteria, the most primitive of lifeforms? How can evolution hope to explain rotary engines with highly efficient, fine-tuned moving parts, in the earliest cells? They cannot.Chinese Fossil Bed Astounds Paleontologists 02/21/2003 The Feb. 20 issue of Nature has a review article on the rich and well-preserved Cretaceous fossils in Liaoning province, China, dubbed the Jehol Biota. The beds of volcanic tuff were so ideal for fossil preservation, they contain soft tissue impressions of feathers, fur, and stomach contents. An abundance of dinosaurs, birds, mammals, fish, insects, amphibians, conifers and flowering plants are well represented, sometimes with 3D impressions and some with hundreds of specimens of certain species in one spot. Famous dinosaurs found in the area include tyrannosaurids, titanosaurian sauropods, velociraptors, ankylosaurs and ceratopians. Also found are pterodactyls, pterosaurs, and the most significant discoveries are undoubtedly the non-avian coelurosaurian theropods, the diverse avifauna and a variety of mammals, all of which have impacted on wide-ranging evolutionary debates. From this region have come the recent claims of feathered dinosaurs and early birds, possible ancestors of flowering plants and early representatives of placental mammals. The authors Zhou, Barrett and Hilton describe dinosaur and bird specimens which provide additional, indisputable support for the dinosaurian ancestry of birds, and much new evidence on the evolution of feathers and flight. They conclude, The spectacular fossils of the Jehol Group have already provided many important insights into the evolution of birds, angiosperms and mammals. Nevertheless, the rate of fossil discovery presently outstrips the rate of description, and detailed monographic treatments of all species from the biota are needed if the full potential of these deposits is to be realized. The Jehol Biota currently represents our best chance of viewing the composition and dynamics of an intact Early Cretaceous terrestrial ecosystem: continuing study of the fauna, flora, taphonomy and palaeoenvironment is likely to yield exciting new results for years to come. China has become one of the worlds hottest fossil collecting spots. These fossils surely deserve careful examination and study. The article here, however, is so impregnated with evolutionary assumptions that trying to get at the actual raw data without the assumptions is like trying to unsalt an egg. The authors are totally convinced that the data support evolution, but some interesting aspects come to light when you read closely (emphasis added in quotes):Cell Repairs its RNA, Too 02/20/2003 The cell has elaborate ways to safeguard its genetic library by repairing DNA, but now scientists are finding the same enzymes can also repair RNA. In the Feb. 20 issue of Nature, Begley and Samson of MIT discuss the findings of Aas et al that RNA methylation damage can be repaired by the same AlkB enzyme that repairs DNA. This is surprising because RNA and proteins were considered more expendable than DNA, but they explain why it makes sense (emphasis added): Why, though, should it be necessary to repair damaged RNA? The answer could be that although DNA is the final arbiter of genetic information, RNA is essential for the most basic biological processes. RNA-based primer sequences are required for DNA replication; and mRNAs, transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs) are all needed during the elaborate process of protein synthesis. Even the formation of peptide bonds by ribosomes (the cells protein-making machines) turns out to require catalysis mediated by rRNAs. Moreover, a battery of small, non-protein-coding RNAs regulates a variety of other cellular processes.Another surprise is that the repair mechanism seems to be able to distinguish between DNA and RNA, and between toxic methylation damage and normal biological methyl groups attached to some RNAs. Begley and Samson think it not unlikely that DNA and RNA might overlap in other ways, such as in cell signalling. Update 06/16/2003: In the June 17 issue of Current Biology, Alfonso Bellacosa and Eric G. Moss from the Fox Chase Cancer Center in Philadelphia remind us that RNA in a cell is subject to many of the same insults as DNA and that the information content of cellular RNA is greater than that of the chromosomal DNA because almost all of RNAs sequences have functional significance (messenger RNA and transfer RNA), whereas only 3% of the DNA has coding potential. Since RNA shows significant response to anticancer agents, the authors suppose that newly-discovered RNA repair pathways are important for preventing cancer: A cell has a great investment in its RNAs they are working copies of its genomic information. The study of mRNA biogenesis in the last few years has revealed an elaborate surveillance mechanism involving factors such as the UPF proteins that culls aberrantly spliced mRNAs and mRNAs with premature termination codons. There might be a hint that such RNA quality control mechanisms go awry in cancers, just as DNA quality control mechanisms do, where aberrantly spliced transcripts accumulate in a tumor. Now that the gates are open, we may have a flood of studies on the RNome [the RNA genome] stability and cancer.(Emphasis added in quotes.) This aggravates the chicken-and-egg problem for evolutionists. In the RNA World hypothesis for the origin of life, RNA performed both the information storage and enzymatic functions before these roles were outsourced to DNA and proteins. But how could RNA repair itself? If RNA needs to be protected from damage, the protein repair system would have needed to be there from the beginning. Evolutionists might surmise that different primitive RNAs worked side by side to repair each other, but that strains credibility for a hypothesis already far-fetched.Nature Tidbit: The esteemed journal recently began a feature interviewing practicing scientists. The interviewee in the Feb. 20 issue is a Christian, Mary Schweitzer, who is a pioneer in the field of extracting biomolecules from dinosaur fossils. The Montana scientist, when asked, Assuming the dead can be raised and/or time travel exists, who from the world outside science would you most like to have dinner with? she answered, Jesus Christ - my hero and role model.
Mitochondrial DNA Database Full of Mistakes 02/19/2003 Some of the stories we have been told about evolution in the genes may evaporate with this revelation. The article admits, The mistakes may be so extensive that geneticists could be drawing incorrect conclusions in studies of human populations and evolution. ... Forsters error-detection method, which involves constructing evolutionary trees based on how sequences change, may even underestimate the extent of the errors. There is even a more ominous concern over nuclear DNA: Forster notes that nuclear DNA sequences in public databases are also plagued by errors, and that this may be an even bigger problem, as such mistakes are more difficult to detect. Can we trust the phylogenetic trees evolutionists are building on flawed data?Diatoms Can Withstand Huge Crushing Forces 02/19/2003 The intricate silica shells of diatoms provide strength as well as beauty, says Nature Science Update. German marine biologist Christian Hamm and team put pressure on the tiny glass frustrules and measured the pressure required to break them: 100 to 700 tons per square inch. Thats like a dining table strong enough to hold an elephant, explains Philip Ball, author of the news article. The veneer of holes and grooves makes the shells 60% stronger than they would be if featureless. The diatoms seem to have found a balance between weight, strength and cost of their protective garments, Ball explains, indicating that they can survive claws and jaws of predators and emerge unscathed from predators guts. Ball quotes Karl von Frisch, Nobel biologist famous for studies on honeybees, as hedging about the aesthetics of the beautiful houses diatoms live in: I do not want to wax philosophical about so much useless beauty scattered over the oceans Nature is prodigal. Ball adds in conclusion, But not so prodigal, it seems, as to create beautiful designs without a sound evolutionary reason. The delicate filigree coating in the shells provides strength and beauty. Why must these attributes be mutually exclusive? Gothic cathedrals were ornate but also structurally sound, and medieval chain mail provided protection as well as a display of artistic craftsmanship. There is no reason to exclude useless beauty in the design of diatoms if they were created, and there is no reason for evolution to evolve beauty for microscopic organisms who only need to survive. Look at the star-shaped example in the article and consider that this is just one of many thousands of geometrical shapes produced by these tiny algae.Cell Nucleus More Than Just a Bag of Chromosomes 02/19/2003 Scientists at Johns Hopkins Medical Institutions are finding that the nucleus of the cell is not just a passive storage area for genetic information. Kathy Wilson told the AAAS meeting on the 17th that the nucleus is is really the cells mothership, a crucial and very active source of information, support and control. One amazing feat occurs during cell division. Chromosomes are pulled apart outside of the nucleus, so the nucleus must disappear during the process. It does not just fall apart. Wilson described it as an orchestrated process similar to the pulling apart of the chromosomes. It seems to involve the same structures and the same tiny motors. Its almost a practice run for moving the chromosomes (emphasis added). This is the language of intelligent design, not evolution. Wilsons talk must have provided an interesting contrast to Michael Ruses outburst (see next headline).I.D. Friends, Foes Square Off 02/18/2003 In the spirit of Charles Darwins advice, A fair result can be obtained only by fully stating and balancing the facts and arguments on both sides of each question, University of Central Arkansas Honors College is hosting a Challenge Week next week for supporters and opponents of Intelligent Design theory to make their case before the students. Recently, William Dembski and Michael Ruse presented their opinions about the AAAS policy to oppose I.D. Both sides, originally presented on Research News and Opportunities in Science and Religion, have been reproduced at Access Research Network. Its good whenever students can hear both sides of this issue; this is a positive change from the one-sided indoctrination that has been the rule. If Darwins advice was right, the fair result of watching the ranting and raving of his disciples will be bad for his theory. Get your Baloney Detector out; here is Ruses statement for you to peruse [our comments in brackets]:Mutation Led to Human Creativity 02/17/2003Scientific creationism is as dead as the dodo [bluffing, big lie, and ridicule]. Even ardent American evangelical Christians [generality, bandwagon] are starting to realize that there really is no good scientific evidence [generality] to take the early chapters of Genesis absolutely literally [straw man and equivocation; then why is Answers in Genesis so popular?] Gods creative efforts took more than six days, and Noahs flood did not cover the whole earth [bluffing, authority]. Unfortunately, [value judgment] "creationism lite," [ridicule] better known as intelligent design, continues to thrive like [analogy] a virulent [fear-mongering] social disease [loaded words, association]. Its supporters push it with enthusiasm and skill [should they not?], and by appealing to ignorance [big lie; thats what Darwinists do] and to the American sense of fair play "If they can have their views expounded in schools, why shouldn't we have ours?" [straw man; students should learn critical thinking, not by indoctrination]. It is an ongoing threat [fear-mongering] to biology education [non-sequitur] in state-supported schools [the schools belong to the American taxpayers, not the Darwinists]. Therefore, I welcome [irrelevant] the sound [value judgment] endorsement of evolution and criticism of intelligent design by the [authority] American Association for the Advancement of Science [do you also support their teaching of native American religion?], and I am quite unmoved [who cares what moves you] by the mishmash of half reasons [bluffing, ad hominem] given in defense of intelligent design by William Dembski.Is there any light in this heat? Are we to just accept this tantrum of baseless sound and fury based on his chutzpah? (I have said it before. I will say it again find somebody who cares!) Evolutionists must surely be embarrassed if this is the greatest philosopher on their team. Read the book No Free Lunch, Dr. Ruse, this time with your eyes open. (By the way, youre cute when youre mad.) 50,000 years ago (the conventional wisdom goes), early modern humans in Africa and Neanderthals in Europe produced boringly similar cultural artifacts. Then something happened. Suddenly, modern-looking people began to behave in a modern way, in producing art and jewelry and doing a whole variety of other things that they hadnt done before, claims Richard Klein, Stanford anthropologist. I think there was a biological change - a genetic mutation of some kind that promoted the fully modern ability to create and innovate. He presented his ideas at the Denver meeting of the American Association for the Advancement of Science on Saturday, reports EurekAlert. Well, this is rich. Not one mutation has ever been shown to be truly beneficial in the sense of creating a new organ or function, but here Klein has the humanities born in an instant by mistake. We ask, did the man and his wife both get the lucky mistake at the same time so they could pass it on? How can a paper like this get presented to an association dedicated to the advancement of science? It is based on a lack of evidence, and built on a flawed view of human history and dating that assumes a position (evolution) from start to finish, even when it leads to absurdities. First, he assumes humans arrived via evolution from lower animals, and that Neanderthals were other than human. Then he thinks he knows when they and modern humans lived. Then he assumes the foxp2 gene is responsible for the humanities, and that it mutated exactly 50,000 years ago (when according to him, it could have mutated sometime between last Tuesday and 200,000 years ago.) Then worst of all, he attributes the richness of human culture to a mistake!AAAS Compromises with Superstition 02/16/2003 According to EurekAlert, the American Association for the Advancement of Science has a new way to help native American students learn science: listen to them and learn from them. These students often find Western science difficult to reconcile with their cultural beliefs. A tribal college in Washington invites native American elders to give lectures, and takes students on field trips into their own communities. The idea, according to speakers at the AAAS Annual Meeting, is that the students learn more if they have a cultural context for their studies, but also that native American culture and its integrated view of the world may have much to offer Western science (emphasis added). It is one thing to be a good listener, but it is another to act on bad advice. Most native Americans are wonderful people, and they do have some things to teach westerners, but their traditional philosophy of nature is poison to science. If the AAAS thinks that listening to the spirit of the coyote is going to help them understand the world, science will take an about-face.War Technology Outruns Brain Evolution 02/14/2003 Our weapons have evolved faster than our brains, thinks University of Maine anthropologist Paul Roscoe, according to EurekAlert. We may have nuclear technology, but we still have stone-age brains, he says. It takes one to know one. Is his brain a cut above those in the Pentagon, or shall we conclude his evolutionary thinking is still in the stone age, too? He might have a point in the area of pop music.Cosmic Rorschach Test Interpreted 02/14/2003 What do you see in these colored dots? Some see a Big Bang. Some are so sure about it, they claim it is proof. The newspapers are all abuzz with the latest image from the Wilkinson Microwave Anisotropy Probe, which refined the temperature fluctuations in the Cosmic Microwave Background (CMB) to the highest precision so far. The New York Times, for instance, claims that the new map confirms the Big Bang theory in triumphant detail. (For copy of article, see Access Research Network.) The data are not new, just improved. Is there a Big Bang in the dots? We just see some dots. Actually, the dots indicate to some astronomers that their models were wrong. The standard model of inflation, the one in the textbooks, is wrong. But two wrongs dont make a right. If it is not A and not B, you cannot assume it must be C, unless C is the only other option. By insisting on philosophical naturalism, cosmologists have ruled out a whole class of causes that might just be true, like design. The WMAP press releases are full of hubris about what the dots mean. Weve seen many times before that the same data, using different assumptions, can be used to justify a totally different interpretation. And how do they know these temperature fluctuations have no other cause? Remember how gravitational lenses and cosmic acceleration came out of left field, catching cosmologists off guard? What might be announced next year?Protein Machine Does Gymnastics 02/13/2003 Scientists are bringing into sharper focus an amazing molecular motor named dynein. Dynein is responsible for much of the movement in the cell: the whiplike action of sperm tails, the sweeping action of cilia, and the ferrying of cargo down the microtubule intracellular railroad. The UK research team of Stan Burgess et al in the Feb. 13 issue of Nature imaged thousands of the little molecules (large by protein standards, with a molecular mass of over 500,000) that work something like railroad handcars. They have a ring-shaped hexagonal head of six AAA proteins to which is added a C-terminal domain. Emerging out of one side and in the same plane as the ring is a stalk, which has a structure on the end that attaches to the microtubule. Emerging out the other end is a stem that attaches to whatever cargo needs to be transported. The stem is fastened to the ring by a linker, that seems to act like a ratchet on a gear during the cycle. How does it work? Though the details are still fuzzy, it appears that ATP hydrolysis occurs in the central ring, or head domain; i.e., energy is extracted from ATP, producing ADP and phosphate, putting the machine into a cocked state. This causes a conformational change (parts moving in relation to one another) resulting in a 34o rotation of the ring relative to the linker. The head domain rolls in relation to the stem, producing mechanical spring energy. Since the stalk and stem have some flexibility, they are capable of storing elastic strain energy when the molecule develops force against a load. The movement pops out the ADP, and then the mechanism springs back to its cocked position; the so-called power stroke. Simultaneously, another ATP energy pellet enters the engine for the next cycle. The angle between the stalk and stem thus changes back and forth in a rocking fashion, producing mechanical leverage, as the linker continually engages and disengages in the central ring, like a hook catch on a gear. As a result, the dynein motor slides down the microtubule monorail in 15-nanometer jumps. But thats not all; there is two-way communication between the tip of the stalk and the engine in the head, and even more amazing regulatory mechanisms that tell the motor where and how fast to go. In their News and Views write-up on the paper, entitled Molecular motors: A magnificent machine, Richard B. Vallee and Peter Höök consider this a remarkable gymnastic ability that is rarely seen in motor proteins. The dynein machines actually use the chemical energy stored in ATP to produce force and carry out work. They point out that this action occurs many times per second in the molecular motor. If you cant reach the Nature article, the BBC News has a summary of it that likens dynein to engines with pistons that make wheels turn. One of the researchers is quoted likening the system to a railway network: Our body is full of proteins which form tracks. Along these tracks, molecular motors are the locomotives, transporting a variety of cargoes to wherever they are needed (emphasis added). It is truly exciting to see the inner workings of cellular processes, long hidden from view, coming to light. They are more wonderful than we could have imagined. Burgess et al do not speculate about the evolution of the dynein machines other than to note that parts of the ring are conserved (unevolved). Vallee and Höök, however, speculate that this highly-efficient system evolved from the family of AAA proteins which also have similar ring structures. But this is pure guesswork. The argument runs out of steam if you follow the logic. In the film Unlocking the Mystery of Life, Scott Minnich rebutted this so-called co-option hypothesis, the idea that molecular machines evolved by borrowing parts from other machines. First he pointed out that while some of the parts are similar to others, there are many that are unique, so where are you going to borrow them from? He explained, Eventually, youre going to have to account for the function of every part as originally having some other purpose. So you can only follow that argument so far, until you run into the problem of: youre borrowing parts from nothing.What Next, a Cuddly T-Rex? 02/12/2003 The BBC News reports on scientists who think Tyrannosaurus rex was a slowcoach and spent most of its time scavenging carrion. It is part of the emerging picture of a plodding, less aggressive T. rex., the article says (see also our Feb. 2002 headline). Remember, Walking With Dinosaurs was mostly human imagination. There are limits to what scientists can know from bones. Would you have been able to describe the looks or lifestyle or behavior or capabilities of a skunk or porcupine or platypus, just from looking at the skeleton? The Flintstones might be more accurate than Jurassic Park; Deeno welcoming the master home with slobbering kisses. Maybe velociraptors were cute and dumb. Weve seen several paradigm shifts about dinosaurs recently (see this story, for instance). This one, though still being debated, is surely not the last.Stephen Hawking Fails History 101 02/12/2003 Owen Gingerich takes Stephen Hawking to task for writing a lousy introduction to a lousy book. In a book review in the Feb. 12 issue of Nature, Gingerich dives right in: I am in two minds about this hefty tome. Should I be embarrassed for Stephen Hawking because an enterprising publisher has inveigled him into putting his name to a collection of superseded texts? Or should I be outraged that an eminent scientist, but one with no track record in the history of science, has the arrogance to endorse historical introductions for five classics of science?Neither sounds too flattering. The book is On the Shoulders of Giants: The Great Works of Physics and Astronomy. Gingerich, an astronomer and eminent historian of astronomy, doesnt think much of the editors choice of material or translations, but he trounces Hawking for abetting historical inaccuracies. In addition to mistakenly calling Copernicus a priest, According to Hawking, Aristotle argued that the Earth was round because hulls of ships sailing out to sea disappeared over the horizon before the sails. The argument was made by Ptolemy half a millennium later, but not by Aristotle. Hawkings introduction also says that Western Christendom placed Hell beyond the stars; that Copernicus became a professor of astronomy at Bologna; that he completed De revolutionibus in 1530; that Rheticus relinquished a chair in mathematics at Wittenberg to study under Copernicus; that Copernicus used equants to account for the motion of the Earth; that Osiander placed the word hypothesis on the title page of Copernicus book; and that the world had scarcely become known to be round when Copernicus wrote. None of this is true. No bibliography is provided, so it is difficult to ascertain the source of this disaster.But he saves some kind words for Hawking at the end: The most interesting part of this book is the general introduction; this is quintessential and thoughtful Hawking, clearly carrying his own stamp. He writes about the anthropic principle: If the ultimate theory made a unique prediction for the state of the universe and its contents, it would be a remarkable coincidence that this state was in the small subset that allows life. It is almost worth the price of the book to get this quotation. Maybe he was having a bad day, but the brainy cosmologist clearly was just parroting things from memory without doing the kind of detailed research characteristic of Owen Gingerich. (With all due respect, its much harder from a wheelchair, too.)Poison for your Health 02/12/2003 We cringe at the names of nasty environmental pollutants: dioxin, mercury, lead, carcinogenic chemicals and X-rays. But now, a surprising article on Nature Science Update says we have an attitude problem about toxic substances. Some of these substances may actually be beneficial in low doses. Certain dioxins in low levels, for instance, can reduce tumors, and small amounts of cadmium can increase plant growth. Edward Calabrese and Linda Baldwin of the University of Massachusetts in Amherst, who have studied 5,000 substances, are among a growing number of researchers who feel that the hazardous nature of toxic substances has been overstated. The levels used in studies are not comparable to those normally experienced by humans, Calabrese says. Pharmaceutical companies might well make use of substances considered toxic in large amounts, as is already being done with botulin toxin, one of the deadliest known. Nature says, The debate also raises the question of how clean our environment really needs to be. Some argue that billions of dollars are being wasted ridding the world of substances that are dubbed hazardous, when low levels could actually be a good thing.The public needs re-educating on this subject, thinks Anthony Trewavas of Edinburgh University: Food contains lots of natural chemicals that are as damaging as synthetics. We consume lots of these all the time without harm. In their Commentary in the Feb. 12 issue of Nature, Calabrese and Baldwin shake the traditional belief these substances are bad down to the last drop, in a linear fashion. Instead, the toxicity follows a hormesis curve, a U-shaped pattern which means little is good but at a certain threshold, more is bad. They wax eloquent about the implications of this paradigm shift: It changes beliefs, attitudes, and assumptions, not unlike changing from a Soviet-style society to a western one. It affects policy on the environment and public health, medical practice, and our understanding of cell biology. How sure are they? Using a database with rigorous and clearly defined entry and evaluative criteria, the hormetic model strikingly outperforms the dominant threshold model. The hormetic model is not an exception to the rule - it is the rule. It would be dangerous to go overboard with the ramifications of this story, either to start consuming unsafe substances or to think that small amounts are therapeutic without adequate experimental support. No homeopathic remedies advocated by us (though advocates will try to appeal to this story for support); and yes, toxic waste dumps still need to be cleaned up. Arsenic can kill, even with old lace. We will not even attempt to gauge whether their hormetic model will stand up to scrutiny by other scientists. But it is interesting to remember that toxic chemicals are not evil in and of themselves, despite the skull and crossbones image. It is the concentration and balance of these substances thats important, and how they interact with the proteins and DNA in our cells. Obviously, it depends on the substance. A tiny drop of cyanide can kill an adult. But anything, even those things we deem healthy, like vitamins or water, can be toxic in excess. Rachel Carsons classic Silent Spring portrayed a horrifying image of insecticides ravaging our health and environment and they certainly can but the issue should be the concentration of these substances, not whether they are inherently bad.New Technologies Poised to Look for Life in Space 02/11/2003 What do Kepler and Darwin have in common? Their names have been applied to missions to look for life in outer space. National Geographic News reviews the new technologies under development to answer this age-old question. NASAs Kepler Mission, slated for 2007 launch, will look for earth-sized planets. JPLs Terrestrial Planet Finder (TPF) will study the chemistry of planetary atmospheres to look for clues that life modified the gases. The European Space Agency has plans for a similar array of orbiting telescopes called Project Darwin (though the Beagle 2 gets to Mars next year without a young Darwin aboard). And the SETI Institute is getting a new array of 350 dishes (year 2005) called the Allen Array to search for signals from advanced civilizations. Let them look, but dont hold your breath. Johannes Kepler speculated about life on other planets, but never doubted that the cosmos expressed the handwork of intelligent design. Though he would have supported the exploration of space, he would have debated forcefully against any philosophy that natural causes alone, apart from design from the infinite wisdom of the Supreme Architect described in the Bible could ever have produced planets, stars, or life.Why Do So Many Plant Species Co-exist? 02/11/2003 A tropical forest can have over a thousand different species of trees in one square kilometer. How do so many varieties coexist when they all compete for the same resources? This is the question explored in a commentary by H. C. Muller-Landau in the Feb. 11 Proceedings of the National Academy of Sciences. He reviews the work of Uriarte and Reeve that invokes a game-theoretic approach. They claim their investigation of seed production and size shows that prior evolutionary matching of species competitive investments increases the potential for ecological coexistence. I.e., if the number of plants is greater with two species living together than apart, then their competitive investments will be evolutionarily stable. Muller-Landau concedes, however, that under different parameter values in the model, the opposite outcome can occur. There are many models, he claims, that can produce qualitatively realistic results; but they need now to make predictions and square with observations. Most models are too narrow to incorporate stochastic effects: Unfortunately, we have no good way to quantitatively evaluate such results because the regularity of the trait distribution produced by models will depend on model details, and will vary stochastically to an unknown degree. ... Ultimately, it is this marriage of theory and data that will bring us a better understanding of plant diversity. This is another case of model-making with enormous tweak space that can produce opposite results depending on the parameters chosen. The Uriarte-Reeve model also commits the personification fallacy of game theory applied to mindless plants, as if they are capable of wheeling and dealing and making tradeoffs with each other. This paper contributes nothing to answering the question of why so many diverse kinds of plants coexist in the same ecosystem. As usual, we have to wait for some sweet by-and-by when evolutionary soothsayers might someday interpret the message. Its interesting that the first act of God for man was to plant a garden, filled with an enormous diversity of plants bearing seed and reproducing (not evolving) after their own kind.Scientists Pump the Flagellum Engine 02/10/2003 Japanese researchers have found that flagella, the whiplike propellers that make bacteria swim, can get flooded with too many protons if the pH is lowered inside, reports Nature Science Update. Like a flooded car engine, the motors come to a stop. But they can run fine again if the artificially-induced pH change is reversed. The article concludes by discussing the functional specifications of these molecular machines: This is a motor with quite remarkable properties, says Robert Macnab of Yale University in New Haven, Connecticut, who studies the assembly of bacterial motors. It runs like a battery, moves like a ships propeller, has a gear switch so it can rotate in either direction, and its under the control of information from [the] environment. These are biological functions at their most simplified form, and yet there are 60 different types of components in this little engine.Kendall Powell explains the interest in these motors: Researchers are keen to understand such chemically driven biological motors, which are only millionths of a millimetre across, as electronics do not work on this scale. The bacterial flagellum has become the unofficial mascot of the Intelligent Design movement, since the publication of Darwins Black Box and the film Unlocking the Mystery of Life. And not without cause; this article does nothing to explain how evolution could produce such a molecular machine. It doesnt even broach the subject. On the contrary, it underscores the point that this is an irreducibly complex system. Macnab claims there are 60 different types of components in this little engine. See the picture in the article, and consider also that many bacteria have more than one propeller this species appears to have eight that work in coordinated movement. In addition to all the complexity of each individual flagellum, having a system of eight requires fast signalling across the interior.Discussion 02/07/2003: Dr. Paul Nelson of the Discovery Institute held a live moderated chat on the Cambrian Explosion and the origin of animal body plans, sponsored by the Intl. Society for Complexity, Information and Design. He provided a PDF document with background information for the discussion. Next headline on: Darwinism and Evolutionary Theory. Next headline on: Fossils.
Wages of Sin Dept. 02/06/2003:
The BBC
News has a chilling report on Indias Lost Girls.
Abortion for sex selection has left such a shortage of girls for so long,
that now young men are maturing with no one to marry.
Villages are full of frustrated bachelors; the young girls who
would have been their brides never had the chance to be born.
Ultrasound, giving parents a view of the sex of their unborn
baby, has become a death sentence for females, who are considered
less desirable to many young couples. The ghosts of
missing babies are closing in, writes Jill McGivering, BBC South
Asia correspondent. If newly-weds continue with this brutal
practice of eliminating girls, this whole region is on course for
catastrophe.
Update 02/06/2003:
National
Geographic reports that the Eden
Project has become the third most popular admission-charging
tourist attraction in Britain. The commercial enterprise
transformed an abandoned industrial pit into a virtual
garden of Eden with 4,500 plant species on display.
The Lone Ranger in Science Is Sometimes the Good Guy 02/06/2003 Although Karl Jansky was the first to detect cosmic radio emission, it was Reber who, through his innovative experiments, forceful personality and stubborn persistence, finally convinced astronomers that it might be important and opened a new window on the Universe.After World War II, Former radar scientists and astronomers, primarily in the United Kingdom, Australia and the Netherlands, built a series of ever more powerful radio telescopes. With them, they made remarkable discoveries that have changed our fundamental understanding of the Universe. This is an interesting case study on many fronts, but caution must be exercised in drawing general principles. It is true that it is nearly impossible today to succeed without a thorough scientific education, and very difficult in many fields to avoid pseudoscience without a PhD, peer review and collaboration. (But New Scientist interviews a Royal Society physicist who thinks peer review is meaningless, corrupt, and disintegrating.) Practically gone are the days of the generalist like Huygens or Pascal, or the home scientists like Leeuwenhoek. Theres just too much to know before you can even start. Often it takes funding and elaborate equipment and training to be a scientist, and usually that presupposes rubbing shoulders with professionals at a university or research lab. Goodness knows there are self-appointed quacks around who think their pet theory is going to overturn everything everybody knows. |